Christopher Moore is easily the most entertaining of living comic writers I've come across. While Moore's work lacks the articulated moral philosophy that shines in Vonnegut's best work (and encumbers his weakest), the characters of his novels each cartwheel through their own surreal science-fiction world.
Moore's 1999 novel, The Lust Lizard of Melancholy Cove, is no exception. From somewhere in the Pacific Ocean and into Pine Cove lumbers an evolutionary anomaly fed by Godzilla level radiation, able to effect peoples emotions; at the same time, the local psychiatrist takes all of her patients off their meds. Constable Theo Crowe investigates a string of murders and a town worth of strange behavior. Chaos ensues.
A fun little romp for a weekend.